Remarkably, the toxic configuration

08 April 2014

Key International Hotels Management Co., Ltd has been appointed to manage one of the oldest buildings in the capital. The former Raffles Beijing Hotel in the heart of city is rebranded as Beijing Hotel NUO, which is located at the southern end of Wangfujing Street, at the corner of East Chang’an Avenue with views of the Forbidden City and part of Tiananmen Square. The hotel will feature 171 rooms and suites with various function room spaces that are ideal for weddings, social events and meetings.

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Remarkably, the toxic configuration is often able to interact with other native copies of the same protein and catalyze their transition into the toxic state. Because of this ability, they are known as infective conformations. The newly made toxic proteins repeat the cycle in a self sustaining loop, amplifying the toxicity and thus leading to a catastrophic effect that eventually kills the cell or impairs its function.

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